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1

Leaving group effects in reductively triggered fragmentation of 4-nitrobenzyl carbamates †

Sykes, Bridget M., Hay, Michael P., Bohinc-Herceg, Dubravka, Helsby, Nuala A., O’Connor, Charmian J., Denny, William A.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

2000

Langue:

english

Fichier:

PDF, 217 KB

english, 2000

2

DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY FOR THE DETERMINATION OF A FLUORINATED ANALOGUE OF THALIDOMIDE, N-(2,6-DIOXOPIPERIDIN-3-YL)-3,4,5,6-TETRAFLUOROPHTHALAMIC ACID, AND LENALIDOMIDE

Pather, Kaveshree, Helsby, Nuala A., Palmer, Brian D., Ching, Lai-Ming

Journal:

Journal of Liquid Chromatography & Related Technologies

Année:

2011

Langue:

english

Fichier:

PDF, 306 KB

english, 2011

3

Pharmacogenomics in Papua New Guineans

Tucci, Joseph D., Pumuye, Paul P., Helsby, Nuala A., Barratt, Daniel T., Pokeya, Percy P., Hombhanje, Francis, Somogyi, Andrew A.

Journal:

Pharmacogenetics and Genomics

Année:

2018

Langue:

english

Fichier:

PDF, 221 KB

english, 2018

4

The importance of correct assignment of CYP2B6 genetic variants with respect to cyclophosphamide metabolizer status

Nuala Helsby, Malcolm Tingle

Journal:

American Journal of Hematology

Année:

2011

Langue:

english

Fichier:

PDF, 65 KB

english, 2011

5

ChemInform Abstract: Leaving Group Effects in Reductively Triggered Fragmentation of 4-Nitrobenzyl Carbamates.

Bridget M. Sykes, Michael P. Hay, Dubravka Bohinc-Herceg, Nuala A. Helsby, Charmian J. O'Connor, William A. Denny

Journal:

Année:

2000

Fichier:

PDF, 31 KB

2000

6

Using metabolomic analysis to understand inflammatory bowel diseases

Hui-Ming Lin, Nuala A. Helsby, Daryl D. Rowan, Lynnette R. Ferguson

Journal:

Inflammatory Bowel Diseases

Année:

2011

Langue:

english

Fichier:

PDF, 112 KB

english, 2011

7

Metabolomic analysis reveals differences in urinary excretion of kiwifruit-derived metabolites in a mouse model of inflammatory bowel disease

Hui-Ming Lin, Shelley J. Edmunds, Shuotun Zhu, Nuala A. Helsby, Lynnette R. Ferguson, Daryl D. Rowan

Journal:

Molecular Nutrition & Food Research

Année:

2011

Langue:

english

Fichier:

PDF, 249 KB

english, 2011

8

Aerobic 2- and 4-nitroreduction of CB 1954 by human liver

Magdalene Huen Yin Tang, Nuala A. Helsby, William R. Wilson, Malcolm D. Tingle

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 172 KB

english, 2005

9

Hepatic nitroreduction, toxicity and toxicokinetics of the anti-tumour prodrug CB 1954 in mouse and rat

Magdalene Huen Yin Tang, Nuala A. Helsby, Michael A. Goldthorpe, Kirsty M. Thompson, Saad Al-Ali, Malcolm D. Tingle

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 2.26 MB

english, 2007

10

Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype

Nuala A. Helsby, Wing-Yee Lo, Ian J. Simpson, David M. Voss, Kaye E. Logan, Martin Searle, John B. W. Schollum, Janak R. De Zoysa

Journal:

British Journal of Clinical Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 360 KB

english, 2010

11

The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation

Nuala A. Helsby, Chung-Yee Hui, Michael A. Goldthorpe, Janet K. Coller, May Ching Soh, Peter J. Gow, Janak Z. De Zoysa, Malcolm D. Tingle

Journal:

British Journal of Clinical Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 919 KB

english, 2010

12

Antimutagenic effects of wheat bran diet through modification of xenobiotic metabolising enzymes

Nuala A Helsby, Shuotun Zhu, Amira E Pearson, Malcolm D Tingle, Lynnette R Ferguson

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

2000

Langue:

english

Fichier:

PDF, 243 KB

english, 2000

13

Nontargeted Urinary Metabolite Profiling of a Mouse Model of Crohn’s Disease

Lin, Hui-Ming, Edmunds, Shelley J., Helsby, Nuala A., Ferguson, Lynnette R., Rowan, Daryl D.

Journal:

Journal of Proteome Research

Année:

2009

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2009

14

Metabolomic Analysis Identifies Inflammatory and Noninflammatory Metabolic Effects of Genetic Modification in a Mouse Model of Crohn’s Disease

Lin, Hui-Ming, Barnett, Matthew P.G., Roy, Nicole C., Joyce, Nigel I., Zhu, Shuotun, Armstrong, Kelly, Helsby, Nuala A., Ferguson, Lynnette R., Rowan, Daryl D.

Journal:

Journal of Proteome Research

Année:

2010

Langue:

english

Fichier:

PDF, 1.45 MB

english, 2010

15

Pharmacogenetics of drug-metabolizing enzymes: the prodrug hypothesis

Begg, Evan J, Helsby, Nuala A, Jensen, Berit P

Journal:

Pharmacogenomics

Année:

2012

Langue:

english

Fichier:

PDF, 589 KB

english, 2012

16

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

Spicer, Julie A., Lena, Gersande, Lyons, Dani M., Huttunen, Kristiina M., Miller, Christian K., O’Connor, Patrick D., Bull, Matthew, Helsby, Nuala, Jamieson, Stephen M. F., Denny, William A., Ciccone,

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.96 MB

english, 2013

17

The Association Between Heterozygosity for UGT1A16 , UGT1A128 , and Variation in the Serum Total-Bilirubin Level in Healthy Young Japanese Adults

Moriya, Hiroyuki, Saito, Katsuhiko, Helsby, Nuala, Sugino, Shigekazu, Yamakage, Michiaki, Takasaki, Masahiko, Kato, Hidenori, Kurosawa, Nahoko

Journal:

Genetic Testing and Molecular Biomarkers

Année:

2013

Langue:

english

Fichier:

PDF, 199 KB

english, 2013

18

Aziridinyldinitrobenzamides: Synthesis and Structure−Activity Relationships for Activation by E. coli Nitroreductase

Helsby, Nuala A., Atwell, Graham J., Yang, Shangjin, Palmer, Brian D., Anderson, Robert F., Pullen, Susan M., Ferry, Dianne M., Hogg, Alison, Wilson, William R., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 191 KB

english, 2004

19

Bystander Effects of Bioreductive Drugs: Potential for Exploiting Pathological Tumor Hypoxia with Dinitrobenzamide Mustards

William R. Wilson, Kevin O. Hicks, Susan M. Pullen, Dianne M. Ferry, Nuala A. Helsby and Adam V. Patterson

Journal:

Radiation Research

Année:

2007

Langue:

english

Fichier:

PDF, 532 KB

english, 2007

20

Metabolic Activation of the Antitumor Drug 5-(Aziridin-1-yl)-2,4-Dinitrobenzamide (CB1954) by NO Synthases

Chandor, Alexia, Dijols, Sylvie, Ramassamy, Booma, Frapart, Yves, Mansuy, Daniel, Stuehr, Dennis, Helsby, Nuala, Boucher, Jean-Luc

Journal:

Chemical Research in Toxicology

Année:

2008

Langue:

english

Fichier:

PDF, 253 KB

english, 2008

21

Effect of Nitroreduction on the Alkylating Reactivity and Cytotoxicity of the 2,4-Dinitrobenzamide-5-aziridine CB 1954 and the Corresponding Nitrogen Mustard SN 23862: Distinct Mechanisms of Bioreductive Activation

Helsby, Nuala A., Wheeler, S. James, Pruijn, Frederik B., Palmer, Brian D., Yang, Shangjin, Denny, William A., Wilson, William R.

Journal:

Chemical Research in Toxicology

Année:

2003

Langue:

english

Fichier:

PDF, 176 KB

english, 2003

22

Bystander Effects of Bioreductive Drugs: Potential for Exploiting Pathological Tumor Hypoxia with Dinitrobenzamide Mustards

Wilson, William R., Hicks, Kevin O., Pullen, Susan M., Ferry, Dianne M., Helsby, Nuala A., Patterson, Adam V.

Journal:

Radiation Research

Année:

2007

Langue:

english

Fichier:

PDF, 251 KB

english, 2007

23

Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19

Helsby, Nuala Ann, Burns, Kathryn Elisa

Journal:

Frontiers in Genetics

Année:

2012

Langue:

english

Fichier:

PDF, 590 KB

english, 2012

24

American Composer Sketches: Robert Washburn

Helsby, Nuala Ann, Burns, Kathryn Elisa

Journal:

Music Educators Journal

Année:

1967

Langue:

english

Fichier:

PDF, 532 KB

english, 1967

25

Association between the low‑dose irinotecan regimen‑induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers

Moriya, Hiroyuki, Saito, Katsuhiko, Helsby, Nuala, Sugino, Shigekazu, Yamakage, Michiaki, Sawaguchi, Takeru, Takasaki, Masahiko, Kato, Hidenori, Kurosawa, Nahoko

Journal:

Oncology Letters

Année:

2014

Langue:

english

Fichier:

PDF, 392 KB

english, 2014

26

Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound: Investigative reports

A. Helsby, Stephen A. Ward, Richard, Nuala

Journal:

Acta Dermato Venereologica

Année:

1998

Langue:

english

Fichier:

PDF, 80 KB

english, 1998

27

Unravelling the role of SNM1 in the DNA repair system of T rypanosoma brucei

Sullivan, James A., Tong, Jie Lun, Wong, Martin, Kumar, Ambika, Sarkar, Hajrah, Ali, Sarah, Hussein, Ikran, Zaman, Iqra, Meredith, Emma Louise, Helsby, Nuala A., Hu, Longqin, Wilkinson, Shane R.

Journal:

Molecular Microbiology

Année:

2015

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2015

28

Towards a test to predict 5-fluorouracil toxicity: Pharmacokinetic data for thymine and two sequential metabolites following oral thymine administration to healthy adult males

Duley, John A., Ni, Ming, Shannon, Catherine, Norris, Ross L., Sheffield, Lesley, Harris, Marion, van Kuilenburg, Andre B.P., Mead, Scott, Cameron, Andrew, Helsby, Nuala, George, Rani, Charles, Bruce

Journal:

European Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 609 KB

english, 2016

29

A high incidence of polymorphicCYP2C19variants in archival blood samples from Papua New Guinea

Hsu, Huai-Ling, Woad, Kathryn J, Woodfield, D Graeme, Helsby, Nuala A

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 242 KB

english, 2008

30

Indirect regulation of CYP2C19 gene expression via DNA methylation

Burns, Kathryn Elisa, Shepherd, Phillip, Finlay, Graeme, Tingle, Malcolm Drummond, Helsby, Nuala Ann

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.47 MB

english, 2017

31

Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX® ADME PGx Panel for Pharmacogenomic Profiling

Chua, Eng Wee, Cree, Simone L., Ton, Kim N. T., Lehnert, Klaus, Shepherd, Phillip, Helsby, Nuala, Kennedy, Martin A.

Journal:

Frontiers in Pharmacology

Année:

2016

Langue:

english

Fichier:

PDF, 302 KB

english, 2016

32

Preliminary Evidence for Enhanced Thymine Absorption

Duley, John A., Ni, Ming, Shannon, Catherine, Norris, Ross L., Sheffield, Leslie, Cowley, David, Harris, Marion, van Kuilenburg, André B. P., Helsby, Nuala, George, Rani, Charles, Bruce G.

Journal:

Therapeutic Drug Monitoring

Année:

2018

Langue:

english

Fichier:

PDF, 295 KB

english, 2018

33

The Prevalence, Impact, and Risk Factors for Persistent Pain After Breast Cancer Surgery in a New Zealand Population

Chiang, Daniel L C, Rice, David A, Helsby, Nuala A, Somogyi, Andrew A, Kluger, Michal T

Journal:

Année:

2019

Fichier:

PDF, 277 KB

2019

34

The Prevalence, Impact, and Risk Factors for Persistent Pain After Breast Cancer Surgery in a New Zealand Population

Chiang, Daniel L C, Rice, David A, Helsby, Nuala A, Somogyi, Andrew A, Kluger, Michal T

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 277 KB

english, 2019

35

A simple ex vivo bioassay for 5-FU transport into healthy buccal mucosal cells

Burns, Kathryn E., Allright, Daniel, Porter, David, Findlay, Michael P., Helsby, Nuala A.

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2019

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2019

36

A simple ex vivo bioassay for 5-FU transport into healthy buccal mucosal cells

Burns, Kathryn E., Allright, Daniel, Porter, David, Findlay, Michael P., Helsby, Nuala A.

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2019

Fichier:

PDF, 1.02 MB

2019

37

A case‐control study to assess the ability of the thymine challenge test to predict patients with severe to life threatening fluoropyrimidine‐induced gastrointestinal toxicity

Helsby, Nuala A., Duley, John, Burns, Kathryn E., Bonnet, Claire, Jeong, Soo Hee, Brenman, Elliott, Barlow, Paula, Sharples, Katrina, Porter, David, Findlay, Michael

Journal:

British Journal of Clinical Pharmacology

Année:

2019

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2019